metal ions in biological systems journal

A novel alendronate functionalized nanoprobe for simple colorimetric detection of cancer-associated hypercalcemia. DNA REPAIR: In living cells, higher doses of trans-DDP as compared to cis-DDP are required to bind an equal number of Pt atoms per nucleotide [66]. This finding has been interpreted in terms of a differential repair of adducts of the two isomers [66], but an alternative explanation has also been offered [152]. Cation binding effect on hydrogen bonding and the energetics of proton transfer in the system (CH3)3NH+…−OCOH. 39, 31-74, ChemInform Abstract: Co(III)-Promoted Hydrolysis of Amides and Small Peptides, Mercury in the food web: Accumulation and transfer mechanisms, Molecular modeling of transition metal complexes with nucleic acids and their constituents, Trans-diammineplatinum(II): what makes it different from cis-DDP? Met. The mutagenic effects of trans-a2Pt(II), although weaker than for cis-DDP, point toward DNA as being an important target for trans-DDP as well. Number of times cited according to CrossRef: Dehydroacetic acid Derived Schiff base as Selective and Sensitive Colorimetric Chemosensor for the Detection of Cu(II) ions in Aqueous Medium. Metal Ions in Biological Systems, Vol. Irradiation and free radicals. The Role of Oxygen in Radiolysis of Aqueous Solutions of Magnesium Guanosine-5’-Monophosphate Complexes. In principle, any of the following reasons or combinations thereof might account for the observed differences in biological effects, but some are more likely than others: 1. The purpose of the conference was to present to an interdiscipl inary audience of physical scientists some recent developments illustrating the chemical and environ­ mental participation of the heavy metal ions in the biological system. These effects are currently under more detailed investigation [45] in order to gain further insight into the electronic structure of these ferrocenoyl peptides. Working off-campus? It is to be noted that repair of monofunctional trans-DDP lesions does not require enzymatic repair but rather may be accomplished by any nucleophile within the cell exercising a reasonably high trans influence, e.g., an S-donor of glutathione. Applications, Metal binding and radical generation of proteins in human neurological diseases and aging, Tungsten-Dependent Aldehyde Oxidoreductase: A New Family of Enzymes Containing the Pterin Cofactor, Inhibition of Brain Tubulin-Guanosine 5'-Triphosphate Interactions by Mercury: Similarity to Observations in Alzheimer's Diseased Brain, Biological chemistry of copper-zinc superoxide dismutase and its link to Amyotrophic Lateral Sclerosis, Analytical procedures for the determination of vanadium in biological materials, Manganese metabolism in animals and humans including the toxicity of manganese, The iron responsive element (IRE) family of mRNA regulators. Structural aspects of group I metal ion-nucleoside interactions, International Journal of Quantum Chemistry. Furthermore, gallium also seems to affect intracellular availability of iron already taken up via this pathway, probably due to its inhibitory activity on vacuolar-type H(+)-ATPases. 2. 6210, Succ. Gallium complexes based on other rationales are scarce and, with regard to the well-known antineoplastic potential of this metal, noticeably under-explored. Please check your email for instructions on resetting your password. Nanometals as Promoters of Nutraceutical Quality in Crop Plants. Regulation of iron transport and uptake compared in animals, plants, and microorganisms, Metabolism and Toxicity of Tungsten in Humans and Animals, The impact of mercury released from dental "silver" fillings on antibiotic resistances in the primate oral and intestinal bacterial flora, Metal ion dependent antibiotics in chemotherapy, Detection of chromatin-associated hydroxyl radicals generated by DNA-bound metal compounds and antitumor antibiotics, Cisplatin and derived anticancer drugs: mechanism and current status of DNA binding, Copper and Zinc Complexes as Antiinflammatory Drugs, Antitumor active trans-platinum compounds, Antitumor titanium compounds and related metallocenes, instructions how to enable JavaScript in your web browser. Electrochemical studies of Fc-peptides show that there is a significant influence of the redox potential depending on the amino acid sequence. (1999). Magnesium–DNA interactions and the possible relation of magnesium to carcinogenesis. For helical Fc-oligoprolines, the redox potential of the Fc group makes it easier to oxidize as the oligoproline chain increases in length. Thermodynamics of binding of Li+, Na+, Mg2+ and Zn2+ to Lewis bases in the gas phase. Although we are not yet in a position to distinguish between "sensing" coordination or "sensing" conformation changes, this effect is of interest because it may allow the development of peptidic sensors. Although carefully collected, accuracy cannot be guaranteed. Journal of Molecular Structure: THEOCHEM. This lecture was presented at the IFST, Sorrenti, Italy, May 2–14, 1983. The effects of metal ion contaminants on the double stranded DNA helix and diseases. In the case of trans-DDP, such a reaction leads to removal of Pt from DNA, unlike in the case of cis-DDP (even though we are aware that cis effects may also be operative). 33 , Probing of Nucleic Acids by Metal Ion Complexes of Small Molecules, Protease activity of 1,10-phenanthroline-copper systems, Mercury-responsive gene regulation and mercury-199 as a probe of protein structure, Pau, R. N. & Lawson, D. M. Transport, homeostasis, regulation, and binding of molybdate and tungstate to proteins. (Ed.). 4.2). Not affiliated Angewandte Chemie International Edition in English. permits a number of answers, relating to various aspects of the chemistry of the two compounds, but the crucial one concerning antitumor activity is yet to be answered. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use. Sec. Structure and gas phase stability of complexes L... M, where M = Li+, Na+, Mg2+ and L is formaldehyde, formic acid, formate anion, formamide and their sila derivatives. A density functional theory study on the intramolecular proton transfer in 6-thioguanine and alkali metal cations substituted derivatives (M-TG, M=Li+, Na+, K+). Necessity of purification during bacterial DNA extraction with environmental soils. Specifically, trans-DDP cannot form 1,2-intrastrand crosslinks, which represent by far the most abundant adducts of cis-DDP. Electrochemical Investigation of the Ionophore Carboxylic “Lasalocid A” at the Water/1,2-dichloroethane Interface. Interaction of Alkaline and Alkaline-Earth Metal Ions with Nucleosides. Département de Chimie, Université de Montréal C.P. The conference was sponsored by the Central States Universities, Inc. , a consortium of sixteen midwestern univer­ sities, the Center for Educational Affairs, Argonne National Laboratory, and the United States Atomic Energy Commission. (AEMB, volume 40), Over 10 million scientific documents at your fingertips. Gallium has been the second metal to show activity against malignant tumors in humans soon after the establishment of platinum drugs in routine clinical practice. Ions Biol. Although this development is currently focusing on arsenic trioxide, it should be suited to stimulate investigations into the therapeutic potential of other arsenic compounds as well. If you do not receive an email within 10 minutes, your email address may not be registered, A. Montréal, Québec H3C 3V1, Canada. Not logged in book series Vulnerability of DNA hybridization in soils is due to Mg2+ ion induced DNA aggregation. Data provided are for informational purposes only. Advances in Experimental Medicine and Biology 6210, Succ. Share. Coordination chemistry of a neglected relative of cisplatin and its interaction with nucleic acids, Targeting of nucleic acids by iron complexes, Interaction of mercury with nucleic acids and their components, Molybdenum Enzymes in Reactions Involving Aldehydes and Acids, Zinc complexes as targeting agents for nucleic acids, Lanthanide-catalysed hydrolysis of phosphate esters and nucleic acids, Porphyrin and metalloporphyrin interactions with nucleic acids, Lanthanide ions as luminescent probes of proteins and nucleic acids, Complexes of lanthanide ions with amino acids, nucleotides, and other ligands of biological interest in solution, Lanthanides as shift and relaxation agents in elucidating the structure of proteins and nucleic acids, Ferrocenoyl Amino Acids and Peptides: Probing Peptide Structure, Microbial iron transport: Iron acquisition by pathogenic microorganisms, Cell responses to lanthanides and potential pharmacological actions of lanthanides, Electrochemically activated nucleic acid oxidation, Current status of structure-activity relationships of platinum anticancer drugs: activation of the trans geometry, Mimicking biological electron transfer and oxygen activation involving iron and copper proteins: a bio(in)organic supramolecular approach, Proteins that bind to and mediate the biological activity of platinum anticancer drug-DNA adducts, Cisplatin and related anticancer drugs: Recent advances and insights, pH-dependent organocobalt sources for active radical species: a new type of anticancer agents, Magnetic resonance contrast agents for medical and molecular imaging, Gallium and other main group metal compounds as antitumor agents, Metal Complexes as Therapeutic Agents in Nitrogen Monoxide Modulation, The effect of cytoprotective agents in platinum anticancer therapy, Lanthanide ions as magnetic resonance imaging agents.

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